Macrolane is a gel compound made of non-animal hyaluronic acid used for enhancing the calves and buttocks. It is sometimes used as an alternative to breast augmentation surgery. The procedure begins with the creation of a small incision in the treatment area. A thin tube, or cannula, is used to inject the Macrolane gel into the subcutaneous layer (inner layer) of the skin. The procedure generally lasts 45-60 minutes. Antibiotics are given either before or after the treatment to reduce the risk of infections.