Artefill is injectable dermal filler made of synthetic microspheres and bovine (cow) collagen. It is used primarily to treat nasolabial creases, lines and folds in the face. The injection sites are injected with Artefill and then the injected areas are massaged and the results are evaluated. The treatment comprises two sessions each that are 15 to 30 minutes in length. There must be a gap of 3 to 6 weeks between two consecutive sessions.